Barry Sanders
The Detroit Lions selected Heisman-winning running back Barry Sanders with the third overall pick in 1989, and though he never played in a Super Bowl, Sanders amassed one of the most decorated individual careers in NFL history. He appeared in ten Pro Bowls and was named the NFL MVP in 1997 after becoming the third player to rush for over 2,000 yards in a season, but only two years later he made the shocking decision to retire in full health. Despite his early exit, the reason for which was never fully clear, his achievements have stood the test of time, as he still has the third most all-time rushing yards in NFL history.