Andrew Luck
The Colts found themselves in an ideal situation with the first overall pick when Luck left Stanford to enter the NFL Draft in 2012. Touted as a generational talent at quarterback, Luck was the heir-apparent to Peyton Manning, hopefully putting the Colts in good hands for at least the next decade. Luck lived up to the expectations at first, leading Indianapolis to the play-offs in his first three seasons, but injuries to his shoulder and kidney in 2015 caused him to miss 26 games over the next three years. He returned to form in 2018, but a lingering leg injury in the 2019 off-season made him decide to hang up the cleats for good.