Rocco Baldelli
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The sixth overall pick of the 2000 draft flew through the minors to debut with the Devil Rays on opening day in 2003. He hit .289 that year and stole 27 bases while playing an impressive center field. He had similar success the following year, but missed 2005 due to a mysterious ailment that stumped doctors. He’d eventually be diagnosed with mitochondrial channelopathy, which limited him to 227 games from 2006 to 2010.